Perlane is the newest member of the Restylane family of products. The primary difference between Restylane and Perlane is that the hyaluronic acid gel particles in Perlane are larger than those found in Restylane. Perlane's larger gel particles offer enhanced volume and lifting power, ideal for wrinkle and fold correction in deeper layers of the skin. Perlane is commonly used for lip enhancement, wrinkle correction, moderate to severe facial folds, smile lines and thin superficial lines around the eyes, mouth and forehead. Perlane is made by Medicis, which also makes the wrinkle filler Restylane. Both products contain hyaluronic acid. Perlane's larger gel particles can reach the deep layers of the skin, offering enhanced volume and lifting power. Perlane has been used safely by dermatologists and plastic surgeons since 2000 outside the U.S. According to Medicis, the maker of Perlane, the effects last for about six months.
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